Hong-Bing Liu, Hua Zhang, Jin-Hai Yu, Cheng-Hui Xu, Jian Ding, and Jian-Min Yue*
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People’s Republic of China
J. Nat. Prod., Article ASAP
DOI: 10.1021/np300004y
Publication Date (Web): March 12, 2012
Chemical investigation into the twigs and leaves of Sapium insigne afforded seven new diterpenoids, sapinsignoids A–G (1–7), together with 10 known diterpenoids. The structures of 1–7 were assigned on the basis of detailed spectroscopic analysis and chemical degradation. Compounds 1–4 exhibited significant cytotoxicity against the A-549 tumor cell line (IC50 0.2–1.8 μM), while compounds 1–3 showed moderate cytotoxicity against the HL-60 cell line (IC50 2.7–6.5 μM).
