Feng Zhang
†, Jun-Song Wang
†, Yu-Cheng Gu
‡, and Ling-Yi Kong
*† † State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People’s Republic of China
‡ Syngenta, Jealott′s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom
J. Nat. Prod., Article ASAP
DOI: 10.1021/np200579b
Publication Date (Web): March 9, 2012
Toonaciliatavarins A–H (1–8), including three new protolimonoids (1–3), two new tirucallane-type triterpenoids (4 and 5), and three new tetranortriterpenoids (6–8), and 10 known compounds were isolated from the stem barks of Toona ciliata Roem. var. henryi. Their structures were identified on the basis of spectroscopic analysis. The absolute configurations of 2 and 8 were determined by ECD calculation. The new isolates were evaluated for their cytotoxicities using six human cancer cell lines and also for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Compounds 4 and 5 showed moderate cytotoxicities, and the protolimonoids (1–3) exhibited marked inhibitory effects on LPS-stimulated NO production.
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