Ke Dong†§, Jian-Xin Pu*†, Hai-Yan Zhang‡, Xue Du†, Xiao-Nian Li†, Juan Zou†, Jian-Hong Yang†, Wei Zhao†, Xi-Can Tang‡, and Han-Dong Sun*†
† State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic of China
‡ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China
§ Graduate School of the Chinese Academy of Sciences, Beijing 100039, People’s Republic of China
J. Nat. Prod., 2012, 75 (2), pp 249–256
DOI: 10.1021/np200937h
Publication Date (Web): February 13, 2012
Eleven new dibenzocyclooctadiene lignans, polysperlignans A–K (1–11), and eight known analogues (12–19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against β-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays.
