Yuan-Wei Liu†, Yuan-Bin Cheng†, Chia-Ching Liaw†, Chung-Hsiung Chen†, Jih-Hwa Guh†, Tsong-Long Hwang‡, Ji-Shu Tsai§, Won-Bo Wang§, and Ya-Ching Shen*†
† School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan
‡ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
§ Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan
J. Nat. Prod., Article ASAP
DOI: 10.1021/np200932k
Publication Date (Web): March 19, 2012
Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1–4), callilongisins A–D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17),13-dien-15-oic acid, 5-hydroxy-3,6,7,4′-tetramethoxyflavone, and artemetin. Compounds 1–3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.
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